Das L3S ist ein Forschungszentrum für grundlagen- und anwendungsorientierte Forschung im Bereich Digitale Transformation sowie Data- und Web-Science. L3S-Forscher entwickeln zukunftsweisende Methoden und Informationstechnologien für intelligente, zuverlässige und verantwortungsvolle Systeme, welche zur Gestaltung der digitalen Transformation und zur nachhaltigen Innovation beitragen. Der Wissentransfer in Wirtschaft, Politik und Gesellschaft bildet einen zentralen Baustein der Aktivitäten des L3S.

Das L3S erforscht die Auswirkungen des digitalen Wandels, um aus den Erkenntnissen Handlungsoptionen, -empfehlungen sowie Innovationsstrategien für die Wirtschaft, die Politik und Gesellschaft herzuleiten. Durch Forschung, Entwicklung und Beratung trägt das L3S gemeinsam mit seinen Partnern zur digitalen Transformation insbesondere in den Bereichen Mobilität, Gesundheit, Produktion und Bildung bei.

Das L3S ist eine gemeinsame Einrichtung der Leibniz Universität Hannover und der Technischen Universität Braunschweig mit rund 150 Wissenschaftlern aus unterschiedlichen Disziplinen an Universitäten und einem Leibniz-Institut (der TIB). Das aktuelle jährliche Drittmittelvolumen des L3S beträgt etwa 6 Mio. Euro, Niedersachsen fördert das L3S zusätzlich mit jährlich etwa 2 Mio. Euro. Das L3S wurde 2011 und 2014 vom Wissenschaftsrat als exzellente Einrichtung evaluiert, führend im Bereich Web Science.

• Steve’s Ultimate Air is a top rated AC Repair in the Phoenix, AZ metro area based in Chandler. https://stevesultimateair.com/ac-repair phoenix/ (2004).
• The potential therapeutic applications and mechanisms of action of Cryptomphalus aspersa (snail) extracts in dermatology and wound healing. Das, Priyam Jyoti; Laskar, Moksood Ahmed; Kalita, Juganta Kumar; Mohan, Hrithik Rikhav; Deka, Anjanjyoti; Ahmed, Nasim; Dutta, Biki (2024). 18(2) 110–117.

  Cryptomphalus aspersa, commonly known as the garden snail, has emerged as a promising therapeutic agent in the fields of dermatology and wound healing. This review explores the diverse therapeutic applications and underlying mechanisms of action of Cryptomphalus aspersa extracts. With a rich history in traditional medicine and growing scientific evidence supporting their efficacy, snail extracts offer multifaceted benefits including anti-inflammatory, antioxidant, collagen-stimulating, and immunomodulatory activities. In dermatology, snail extracts have shown promise in managing conditions such as acne vulgaris, atopic dermatitis, photoaging, and hyperpigmentation, while also demonstrating efficacy in promoting wound healing in various types of wounds, including full-thickness and chronic wounds. Mechanistically, snail extracts modulate inflammatory pathways, neutralize oxidative stress, stimulate collagen synthesis, and regulate immune responses, contributing to their therapeutic effects. While the potential of Cryptomphalus aspersa extracts is vast, further research and clinical trials are warranted to establish their efficacy and safety profiles for specific dermatological conditions and wound types. Overall, Cryptomphalus aspersa extracts represent a novel and promising approach in dermatology and wound healing, offering a natural and multifaceted solution for improving skin health and promoting tissue repair.
• Theoretical insights into telemedicine and healthcare ICT: lessons from implementation in Africa and the United States. Ijeh, Scholastica; Okolo, Chioma Anthonia; Arowoogun, Jeremiah Olawumi; Adeniyi, Adekunle Oyeyemi (2024). 18(1) 115–122.

  This review paper explores the theoretical insights and practical lessons learned from the implementation of telemedicine and healthcare Information and Communication Technology (ICT) in Africa and the United States. By comparing the challenges, strategies, and outcomes of telemedicine initiatives in these diverse healthcare settings, the paper highlights the importance of context-specific solutions, supportive policy frameworks, and the role of technology in overcoming barriers to healthcare access. The analysis reveals key theoretical frameworks such as the adaptive model of telemedicine implementation and the ecosystem approach, emphasizing the necessity for flexibility, interoperability, and equity in telemedicine services. The paper concludes with implications for healthcare providers, policymakers, ICT developers, and recommendations for future research, aiming to enhance the global understanding and deployment of telemedicine.
• Comparatively tested potential risk factors across survivors and non-survivors critically patients. Alshwaheen, Basim Nawaf; Rabab’ah, Mo’ath Musa Falah; Albarbbarawi, Suhaib Adel Mahmoud; Alkhrissat, Tariq Saber Mohammad; Al-Rawashdeh, Amro Nayif Ghaleb (2024). 18(1) 123–135.

  Background: The risk factors associated with mortality in critically ill patients have been the subject of numerous studies. However, a considerable amount of variation is evident when one considers the dispersion of patients, the geographical spread, and the classification of healthcare establishments. Aim: The purpose of this study was to compare potential risk factors between Survivors and Non-Survivors, including demographics, anthropometrics, kidney and liver indices, complete blood counts, and biochemical assays. Patients whose condition is critical. Methods: An ICU retrospective investigation was conducted in Jordan, where critically ill patients with surgical and medical conditions were examined. Using the Electronic Medical Record System (Hakeem), the study analysed data and classified patients into two cohorts according to their survival status. Demographic information, clinical characteristics, insulin administration rate, blood glucose levels, dosing schedules for vasopressors, and the burden of comorbidities were all included in the data. The research was granted approval by the Institutional Review Board committee of the Royal Medical Services, Jordan. Results: The research examined the male-to-female ratios among COVID-19 patients and classified them into six distinct age groups. A significant proportion of critical patients, ranging in age from 50 to 60, exhibited elevated corrected sodium levels and a diminished normontraemia status. Higher albumin levels and mean arterial pressures were associated with survivors, whereas a greater proportion of non-survivors were underweight and had a low BMI. A normal temperature was observed in the majority of critically ill patients, whereas non-survivors exhibited elevated fractional blood glucose levels and estimated creatinine clearances. The research emphasises the significance of treatment outcomes and patient demographics. Conclusion: SI may be a more accurate prognostic indicator than non-septic patients due to the effect of norepinephrine, a vasopressor, on heart rate and systolic blood pressure, which may account for the difference in SI values between the two groups.
• Prediction quality of patients’ composited outcomes of interest and how much variations on the outcomes explained by the patients’ sodium levels. Alshwaheen, Basim Nawaf; Rabab’ah, Mo’ath Musa Falah; Albarbbarawi, Suhaib Adel Mahmoud; Alkhrissat, Tariq Saber Mohammad; Al-Rawashdeh, Amro Nayif Ghaleb (2024). 18(1) 136–141.

  Background: Hypernatremia can be caused by medications, glucose/urea-related hyperosmolarity, overdiuresis, compartmental fluid distribution imbalances, iatrogenic hypertonic saline excess, renal concentrating performance defects, overdiuresis, and hypermetabolic states. Patients who are in critical condition, encompassing ailments of the heart, liver, lungs, brain, and kidneys, frequently manifest hyponatremia (sodium < 135 mEq/L). Similar to hypernatremia, hyponatremia signifies the severity of the illness and a bleak prognosis. Hyponatremia is less lethal than central pontine myelinolysis, which overcorrects sodium concentrations urgently. Aim: The objective of this research endeavour was to investigate the strength of correlations, the extent to which the independent variables account for the overall variability in the dependent variable, and the accuracy of the dependent variable's predictions. In addition, the purpose of this test was to extract the coefficients required to present the Binary Logistic Regression models that were investigated. Methods: Between May 2018 and May 2021, this study examined two Na-based prognosticators for overall mortality in critically ill patients admitted to the King Hussein Medical Centre. An investigation was conducted on 2155 cases utilising Receiver Operating Characteristic (ROC) and Sensitivity Indices Test analyses to ascertain the most effective cut-off points, specificities, sensitivity, predictive values, likelihood ratios, Youden and accuracy indices, and mortality rates. The research discovered that serial termination points with lower values suggested more robust evidence for a positive actual state, whereas higher values suggested less robust evidence for a negative actual state. A Binary Logistic Regression (BLgR) test was performed to examine correlations, the extent of total variations in the dependent variable, and the accuracy of the prediction for each Na-related mortality prognosticator in relation to overall mortality. The analysis was conducted utilising version 25 of SPSS for Windows. Results: The research revealed that the AUROC for cNa was considerably greater in magnitude compared to its prognosticator that is genealogically related to Na. 129.35 mEq/l and 131.05 mEq/l were the optimal cut-off points, TPRs, TNRs, PPVs, NLRs, YIs, and AIs for the two comparative Na investigated statutes. The BLgR models were developed in order to simulate the relationship between the corrected and measured Na levels of patients and their overall mortality rate. For critically ill patients, the probabilities of overall mortality at the optimal cutoff operating Na levels were 79.59 and 81.62 percent, respectively.
• An analysis of order utilization and overall costs secondary to an extended length of stay in hospitalized patients pending discharge to long term care facilities during the peak of Omicron. Martinez, Karina Alexandra; Mayas, Tiffany Nadia (2024). 18(1) 142–146.

  During the covid pandemic there was an influx of patients admitted to hospitals worldwide. This resulted in a presumptive overuse of resources, increased utilization costs, and decrease in hospital bed availability. This study focuses on patients admitted with a positive covid test, who required transfer to a long-term health facility after the acuity of their symptoms no longer required hospitalization but necessitated an extended length of stay due to acceptance into these facilities. Such facilities included: alternative living facility, skilled nursing facility, psychiatric institutions, or hospice. Wherein these facilities required a negative Covid PCR test or required a certain time frame to have elapsed after a positive test prior to accepting or recovering a patient. This study utilized patient records from Keralty Hospital, with admission during the 2022 peak of Omicron (January 31, 2022- February 13, 2022). Patient inclusion criteria was if they had a positive covid test on admission and experienced an extended length of stay over 2 days pending discharge to a long-term care facility. A quantitative/qualitative analysis was conducted of all orders placed subsequent to the first discharge order, and the number of additional days spent at the hospital. Correlations regarding total bed cost, and total overall, were then calculated using single tailed p values utilizing Prism 9 GraphPad software. Our research findings indicate there was a significant correlation between the number of extended hospitalization days and total bed costs but no correlation in the total overall costs or initial length of stay for each patient.
• Verification of analytical performance of Unsaturated iron binding capacity (UIBC) assay on the Abbott Alinity ci®: Experience of the central laboratory of Mohammed VI University Hospital of Oujda. khamlichi, Imad-Eddine El; Mokhtari, Issam; Douzi, Nisma; Grari, Oussama; Beyyoudh, Soufiane; Moujtahide, Dounia El; Sebbar, El Houcine; Choukri, Mohammed (2024). 18(1) 147–153.

  The verification of analytical methods is a requirement outlined by the International Organization for Standardization (ISO). This process involves evaluating the performance of an analytical method according to a well-defined protocol and subsequently comparing it with pre-established analytical objectives. In our study, we conducted an evaluation of the analytical performance of the unsaturated iron binding capacity assay using the Abbott kit on the Alinity CI analyzer in the biochemistry laboratory of Mohammed VI University Hospital in Oujda. The methodology employed adheres to the recommendations of the French accreditation committee (COFRAC) accreditation technical guide SH GTA 04, focusing on the assessment of reproducibility and repeatability. Overall, the results obtained from the study are considered satisfactory and align with the acceptability criteria recommended by the supplier. It's important to note that the accuracy and reliability of examination results are influenced not only by laboratory personnel, equipment, and environmental conditions, but also by the methods utilized and their eventual validation or verification.
• Echocardiographic imaging of neonatal transposition of great arteries: Rare case report and review of literature. Mehrotra, Akhil; Siddiqui, Faiz Illahi; Shakya, Ujala; Shaban, Mohammad (2024). 18(1) 154–169.

  Transposition of the great arteries (TGA) is a congenital conotruncal abnormality characterized by discordant connections between the ventricles and great arteries, with the aorta originating from the right ventricle (RV), and the pulmonary artery (PA) originating from the left ventricle (LV). The two main types of TGA are complete transposition or dextro-transposition of the great arteries (D-TGA), commonly referred to as D-loop, and congenitally corrected transposition (CCTGA), commonly referred to as L-loop or L-TGA. In D-TGA, the connections between the ventricles and atria are concordant, whereas in CCTGA they are discordant, with the left atrium connected to the RV, and the right atrium connected to the LV. Imaging plays an important role in the evaluation of TGA, both before and after surgery, for helping define the anatomy, quantify hemodynamics, and evaluate complications. Transthoracic echocardiography is the first-line imaging modality for pre-surgical planning in children with TGA. MRI provides comprehensive morphologic and functional information, particularly in adults after surgery. CT is performed when MRI is contraindicated or expected to generate artifacts. We are reporting an extremely rare and unique case of 25-day old male neonate, suffering from TGA with a side to side alignment of great arteries, accompanied by a moderate sized restrictive atrial septal defect (ASD) and an ascending aortic aneurysm (AAA).
• A case report on cocoon abdomen. Anil, Aparna; Santhosh, Anjitha; Basheer, Azeem Mohamed; L, Drishya.; Dharan, Shaiju. S.; Dharman, Dhanya (2024). 18(1) 170–174.

  Abdominal Cocoon is one of the rare causes of intestinal obstruction. A complete or partial small bowel encapsulation caused by thick fibro collagenous membrane. Cocoon Abdomen is otherwise called Sclerosing Encapsulating Peritonitis (SEP). This SEP is divided into two: abdominal cocoon (AC) also known as idiopathic or primary sclerosing encapsulating peritonitis, which is extremely a rare and secondary sclerosing encapsulating peritonitis, which is a common one. Symptoms are nonspecific and preoperative diagnosis was extremely difficult. Surgery is very essential to take membrane samples that confirm diagnosis and for treatment.
• Maternal and fetal outcome in COVID 19 positive pregnant women with thyroid dysfunction. Mirza, Sarah Navid; Vijaykumar, Rathod Raj; Sahu, Latika; Singh, Preeti; Shakarwal, Shalini (2024). 18(1) 182–192.

  Background: Normally functioning thyroid glands are able to meet the increasing need for hormones during pregnancy and keep thyroid hormone levels within normal limits. However thyroid dysfunction in pregnancy can cause adverse maternal and fetal outcomes like pre-eclampsia and gestational hypertension, antepartum hemorrhage, anemia, preterm delivery, low birth weight and addition of SARS-CoV-19 infection can worsen the perinatal outcome. In present ambispective study, obstetric outcomes of 32 cases of COVID 19 positive pregnant women with thyroid dysfunction (Group A) were compared with 32 cases of COVID 19 negative pregnant women with thyroid dysfunction (Group B). Results: Pregnancy induced hypertension (PIH) was the most common antepartum complication noted in both the groups (28.1% vs 12.5%). Group-A had 40.6% LSCS rate whereas it was 37.5% in group-B. Average period of gestation at delivery was 38 weeks in both the groups. The most common neonatal complication was low birth weight (9.4%) in both the groups. Group A was also associated with meconium aspiration syndrome (MAS) (9.4%), neonatal sepsis (6.2%) and transient tachypnoea of newborn (TTN) (3.1%). NICU admissions were 37.5% in group A while only 6.25% in group B. (p value <0.01). Most common indication for NICU admission was MAS (9.4%) in group A. It was observed that incidence of pregnancy induced hypertension (PIH) and neonatal complications including NICU admissions were increased in presence of both COVID 19 and thyroid disorder as compared to only thyroid disorder in pregnancy. Multi-disciplinary approach with more vigilant monitoring can help reduce perinatal morbidity and mortality.
• Aquaporins: Navigating the channels of cellular hydration. REDDEMMA, MAADHU; POOJITHA, DAMA; JYOTHSNA, AVULA; SAI, DHONI CHARAN; SUJEEVAN, RAGALA (2024). 18(1) 175–181.

  Aquaporin’s are water channel proteins found in all plasma membrane of various cells in all forms of life from bacteria to mammals. Around 17 mammalian aquaporin’s have been identified till date, which are classified into 3 subcategories based on their permeability. In normal physiology, AQPs serve as essential modulators of fluid transport and homeostasis in multiple organs and tissues. Altered expression of aquaporin’s is linked to numerous pathologies including fluid dysregulation, tumor metastasis and traumatic injury. Although some potential AQP modulators have been identified, challenges associated with the development of better modulators, include the suitability of the assay methods used to identify modulators and the drug ability of the target. The present review focus on aquaporin types and their altered conditions along with role of aquaporin’s in cancer and other diseases.
• Affordable Construction in Pakistan: Building Your Dream Home on a Budget. William, Jenifer (2024).
• A case report on Multisystem Inflammatory Syndrome in Children (MIS-C) with myocarditis. R, Lekshmi.; Anil, Aparna; L, Drishya.; Dharan, Shaiju. S. (2024). 18(1) 193–195.

  Multisystem Inflammatory Syndrome in Children (MIS-C) is a serious condition that can occur after a SARS-CoV-2 infection, commonly known as COVID-19. It involves fever, organ dysfunction, and increased inflammation markers. It was initially described as a post- infection complication of SARS-CoV-2 virus. With the development of vaccines and the efforts to control the spread of the virus, the incidence of MIS-C has decreased. There is no specific test to diagnosis a patient with this condition For patients with symptoms of MIS-C, clinicians perform a thorough evaluation, which may include blood tests, scans etc. Patients are also tested for the presence of antibodies to SARS-CoV2, the virus that causes COVID-19. When it comes to the treatment of Multisystem Inflammatory Syndrome in Children (MIS-C), it typically involves a multidisciplinary approach and may vary depending on the severity of the condition. Treatment often includes hospitalization for close monitoring and supportive care. This can involve intravenous fluids, medications to reduce inflammation, and management of specific organ complications. In some cases, additional interventions such as immunoglobulin therapy or steroids may be used.
• Buy Verified Cash App Accounts in The Service Provider Company Our Products is 100% Verified Trustable With Guarantee., Buy Verified Cash App Accounts Smmitfarm (24/7 C. support; T. @smmitfarm; W. +1(928)362-5634; S. smmitfarm, eds.) (2024).
• Spinal muscular atrophy: A comprehensive case report. MALLAMPATI, VARSHINI (2024). 18(1) 196–197.

  Muscle Weakness and Atrophy, Hypotonia, Progressive Degeneration, Motor Function Impairment are hallmarks of Spinal Muscular Atrophy, a neuromuscular genetically inherited disorder that causes muscle weakness and wasting usually diagnosed in infancy or early childhood and rarely identified in adults. The genetic components of the disease are inherited, meaning that the afflicted individual receives the gene from a parent with the same genetic makeup. It is inherited in an autosomal-recessive manner. The survival motor neuron gene 1 (SMN1) is the gene responsible for the most prevalent kind of SMA. A patient with Spinal Muscular Atrophy is described, associated their clinical with and genetic features.
• How Much Does A Chiropractor in Macomb, Michigan Cost Without Insurance. Franco (Franco, ed.) (2024).
• Anti-obesity and hypo-lipidemic activity of Eleusine indica against high fat diet-induced obesity in rats. Kadam, Dipawalee D.; Wankhede, Sumit L.; Jadhao, Umesh T.; Sable, Shital D.; Muneshwar, Pradnya D.; Raut, Mangesh D. (2024). 18(1) 198–204.

  In present study the pharmacological activity of Eleusine indica extract for Anti-obesity and Hypo-lipidemic effects in animal model. The phytochemical components of extract like terpenoids, saponin, alkoids and flavonoids, which already implicated for anti-hyperlipidemic activity. There was a comparative reduction in body weight of methanolic extract of Eleusine indica treated groups at “200”and ‘400 mg’/kg, atorvastatin “10 mg”/kg .when compared to the high fat diet administered rats. The results also suggested that methanolic extract of Eleusine indica at “200mg”/kg and 400 mg/kg are capable preventing the body weight gain this result was in accordance with the result reported from previous study where a dose depedent decrease in the body weight was observed. This study also proved remarkable increased in locomotor activity when compared with high fat administered rats. Whereas in obese rats there was reduction in locomotors activity. Present study also reported that methanolic extract of Eleusine indica significant [P<0.001] decreased the level of LDL and Triglycerides also apart from reduction in weight, supplementation with MEEI was observed to attenuate significantly [P<0.01] decreased the levels of total cholesterol and significantly increased [P<0.01] the HDL level in rats feed with HFD.
• Buy Verified Cash App Accounts - 100% Safe & BTC Enabled support, 24/7 Customer; @smmitfarm, Telegram:–; +1(928)362-5634, Whatsapp:; smmitfarm, Skype:– (S. Buy verified cash app accounts with login access from US as phone number, ed.) (2024).
• Addressing health disparities through IT: A review of initiatives and outcomes. Ijeh, Scholastica; Okolo, Chioma Anthonia; Arowoogun, Jeremiah Olawumi; Adeniyi, Adekunle Oyeyemi (2024). 18(1) 107–114.

  This paper provides a comprehensive review of information technology (IT) initiatives to address health disparities and evaluate their outcomes. Health disparities, defined as unequal health outcomes and access to healthcare across different population groups, are a persistent challenge globally. IT, including telehealth, electronic health records (EHRs), mobile health (mHealth) applications, and data analytics, presents innovative opportunities to mitigate these disparities. The review discusses the successes and challenges of these IT initiatives, highlighting their potential to enhance healthcare access, improve the quality of care, and promote health equity. Telehealth has been instrumental in bridging the gap for remote and underserved populations, while EHRs have improved care coordination. mHealth applications offer personalized health interventions, and data analytics is crucial in identifying and addressing health disparities. However, the effectiveness of these IT solutions is hindered by barriers such as the digital divide, lack of digital literacy, and privacy concerns. The paper calls for continued investment in accessible and equitable IT initiatives. It emphasizes the need for a multidisciplinary approach involving policymakers, healthcare providers, and IT professionals to implement effective solutions. Through this review, the paper aims to contribute to understanding how IT can be leveraged to combat health disparities, offering insights for future research and policy development.
• Achieve a Confident Smile: Dental Implants at Dentistium. Dentistium (Dentistium, ed.) (2024).
• Treatment of bunionette deformity with distal oblique sliding osteotomy. Zaizi, A.; Boussaidane, M.; Benyass, Y.; Boukhris, J.; Benchebba, D.; Chafry, B.; Boussouga, M. (2024). 18(1) 209–213.

  Background: Tailor’s bunion is a bone prominence on the lateral side of the fifth metatarsal head, it is most often associated with soft tissue bursitis and a tender callosity. In the current series, we evaluated a technique of Distal Oblique Sliding Osteotomy using K-wire fixation. Materials and methods: We present a retrospective and consecutive series concerning six patients (six feet) suffering from symptomatic bunionette deformity treated through the DOSO with k-wire fixation. We describe this procedure, their results, and short-term follow-up. Results: At 12 months follow-up, the results were satisfactory in 5 feet, fair in one patient following the American Orthopaedic Foot and Ankle Society (AOFAS) score. The average preoperative intermetatarsal 4-5 angle improved from 14,5° (range, 8°-17°) to 5° (range, 5°-9°) and the fifth metatarsophalangeal angle improved from 16.2° (range, 10°-24°) to 3,5° (range, 2°-9°). Conclusion: This technique is versatile, cost-effective (can use a small piece of pins), safe and reliable in comparison to other types of bunionette osteotomy and their osteosynthesis.
• An assessment of the probability of patients experiencing bone pain for early prioritization to the rehabilitation clinic. Khreisat, Eman Farhan Hamdan; Al-Qatamin, Haneen Khaled Khlaif; Hammour, Majd Yaser Salem Abu; Milkonean, Rula Yacoub Thukran; Abbadi, Rawan Bassam Abdullah; Abass, Alia Hani Fadel Abu; Elgazzawi, Tasneem Ali Abdullah (2024). 18(1) 079–093.

  Background: As a result of DEXA and risk factor-based evaluation, which rank patients according to their osteoporosis risk, risk assessment instruments such as the Osteoporosis Self-assessment Tool, Risk Assessment Instrument, and Simple Calculated Risk Estimation were created. Aims: In two phases, the precision of evaluation instruments will be assessed: pre-test, post-test, and pre-diagnostic DEXA will be utilised to determine the accuracy of the assessment tools and pre-test, respectively. Methods: From September to November 2021, this study examines osteoporosis patients at Prince Rashid bin Al-Hasan Military Hospital in Jordan. Bayes' theorem and osteoporosis screening methodologies are utilised to calculate the post-test probability of patients. Evaluation of AUROC and performance metrics will be conducted utilising a ROC curve. The term of the investigation is 2021-2021. Results: The gender distribution of the 206 patients examined in the study was 5.87:1. AUCs SEMs for the binary logistic regression models incorporating independent variables (OST, ORAI, and BAQ) varied in response to the probability of FRAX≥3% versus <3%. FRAX% exhibited the following sensitivity indices: 0.02, 75%, 41.36%, 66.36%, and 41.03%. The innovative quotient (BAQ), which represents the ratio of body weight to age, had respective pre-test probabilities of 0.789±0.033, 0.484±0.042, and 0.254±0.037. Conclusion: The research examined the probability of BLR_BAQ after the test was conducted using OST and ORAI references. Significant AUROCs were observed for all three osteoporosis instruments; however, the performance of the post-test probabilities for FRAX≥3% of the BLR_BAQ model was subpar, as evidenced by both the standards and ORAI inference.
• Hospitalised patients’ albumin-globulin ratio may predict negative clinical outcomes. Alawneh, Zaid Ezzat; Al-Theiabat, Abedal-Rahman Ismail; Al-Shatnawi, Ali Fawzi Ali; Aldeeb, Mohammad Talal Ahmad; Almiqdad, Yarub Mohammad Najeh Raja (2024). 18(1) 021–027.

  Aims: This research assesses the predictive capability of the ratio of serum albumin levels (ALB) to globulins levels (GLB), known as the AGR, and to determine whether this ratio may be used to anticipate adverse clinical outcomes in these patients. Methods: This observational study was conducted at the Prince Rahid bin Al-Hussein Military Hospital in Irbid governorate to analyze medical and surgical adult patients. The study aimed to explore the prognostic performances of the assessed albumin to globulin ratio (AGR) against composited negative clinical outcomes, including a decline in creatinine clearance, liver function indices, systemic inflammatory response syndromes, sepsis, longer hospital stays, and death. Factors investigated included patients' demographics, biochemical and complete blood count laboratory results, and subjective reported data. The study focused on evaluating the AGR as an independent variable for predicting adverse clinical outcomes. The optimal threshold for the tested prognosticator of interest (AGR) was determined, and patients were divided into two groups with lower AGR than the cutoff point. A chi square test was conducted to represent the comparative distribution rates between the investigated variables. Results: A study involving 302 patients found that 51.66% were assigned to Group I, characterized by a lower albumin to globulin ratio (AGR) below the optimal cutoff point of 0.795, and the remaining patients were classified into Group II with an AGR above 0.795. The Pearson correlation coefficient for composite outcomes of interest (cOI) was moderately high in the negative direction for the higher AGR group compared to the lower AGR group. The age distribution was evenly distributed between the lower and higher AGR groups. A binary logistic regression model was created to show the relationship between AGR and the likelihood of adverse clinical outcomes. The prognosticator AGR was evaluated to be 0.928±0.015, with a p-value of less than 0.001, indicating statistical significance. The optimal threshold for the study was 0.795, with a sensitivity of 87.8% and a specificity of 85.23%. Conclusion: Our study found that maintaining an albumin to globulin ratio below 0.795 can have positive effects on hospitalised patients, both medically and surgically admitted, by predicting adverse clinical outcomes.
• An elevated gamma gap as diagnostic tool for acute systemic inflammatory response syndromes in Hospitalized patients. Alawneh, Zaid Ezzat; Al-Theiabat, Abedal-Rahman Ismail; Al-Shatnawi, Ali Fawzi Ali; Aldeeb, Mohammad Talal Ahmad; Almiqdad, Yarub Mohammad Najeh Raja (2024). 18(1) 028–035.

  Aims: This study aimed to investigate the predictive value of the Gamma Gap in relation to the probability of cOI positivity. Our secondary objectives aimed to determine the optimal threshold in the Jordanian tested cohort, beyond which negative adverse outcomes would significantly rise. We aimed to assess the sensitivity and specificity of the Gamma gap and compare it with similar previous studies and other related sensitivity indices. Methods: An observational study was conducted at Prince Rahid bin Al-Hussein Military Hospital to analyze adult medical and surgical patients. The study aimed to examine the prognostic abilities of the evaluated Gamma Gap compared to a combined negative clinical outcome. The study included adult admitted patients with stable baseline renal, liver, hemodynamic, and systemic immune-inflammatory statuses. The study used binary logistic regression to examine the Gamma Gap as an independent variable for predicting adverse clinical outcomes. A sequential statistical analysis of receiver operating characteristic (ROC) testing and sensitivity analysis was conducted to express the predictive utility of the Gamma Gap against the positivity of adverse clinical outcomes. The study also identified the ideal cutoff point for the Gamma Gap, with a value above it indicating a worse outcome and a value below it indicating a better outcome. Results: A study involving 302 eligible patients was conducted to determine the optimal cutoff point for composite outcomes of interest (cOI). The study found that the higher Gamma Gap group had a stronger positive Pearson correlation coefficient than the lower Gamma Gap group. The unadjusted risk estimate was 29.75 (95% CI; 15.78-56.09). The two genders were distributed equally across the groups, with no statistically significant gender distribution rates. Albumin and albumin to globulin ratio levels showed significantly different distributions between the groups. The ages of the tested patients were insignificantly distributed between the groups. A binary logistic regression model was developed to evaluate 83.4% of cases. The prognosticator Gamma Gap performed as expected, with a p-value of less than 0.001 and an evaluation of 0.902±0.018. Conclusion: According to our research, hospitalised patients may benefit from keeping their Gamma Gap below 3.04, and this subtracted biochemical tool can be extremely useful in predicting unfavourable clinical outcomes as well as in the screening, diagnosis, and follow-up of both medically and surgically admitted patients.
• A new era of ICTs for combating symptoms of neurodevelopmental disorders. Pergantis, Pantelis (2024). 18(1) 036–047.

  Information Communication Technology (ICT) is an umbrella definition, where the purpose of its creation and use is to facilitate communication, storage, and transfer of big data and the development and use of the technology that supports it. In contemporary research, several studies have observed attempts to incorporate them in populations with neurodevelopmental disorders (NDDs) to detect/assess, intervene, and improve deficits for the inclusion of these individuals in education and society. This review attempts to explore new universal and mainstream technology and to broaden and provide data for employing it in future research or intervention in the school setting as a complementary addition to education combating core symptoms of the three most recurring NDDs including autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD) and developmental coordination disorder (DCD).
• A mobile app as a gamified early intervention for ADHD students. Kakoura, Eirini; Loukas, Panagiotis; Sideraki, Angeliki (2024). 18(1) 048–053.

  Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent behavioral disorder that typically starts during infancy but can also emerge during adolescence or adulthood. This research study concentrated on developing an engaging supplementary resource to aid children with ADHD who face challenges with executive functions. The gamified system was specifically designed as an Android mobile application, aiming to provide a helpful tool for parents as well as an educational tool for teachers to proceed in early intervention and track the progress of students with ADHD or other special educational requirements.
• Low mathematics performance and the role of digital technologies. Mastrotheodorou, Agathi Stathopoulou Maria (2024). 18(1) 054–063.

  In the current study, we dealt with Dyscalculia, Mathematics Anxiety and Low Intelligence Quotient as factors that contribute to low performance in Mathematics. We investigated the relative effect of Dyscalculia and Mathematics Anxiety on students’ performance. Also, we examined how technology helps the educational intervention in cases of Low Intelligence Quotient. We first present the main characteristics of the three factors and we continue with studies which indicate the way they affect performance in Mathematics. Through the current study we found that Mathematics Anxiety affects more negatively the students’ performance than Dyscalculia does, as Mathematics Anxiety is a broader psychosocial factor that is more difficult to locate and handle. With regards to Low Intelligence Quotient, we concluded that those people can best be educated through technology and specifically through applications that support learning basic Mathematic skills.
• Advantages and disadvantages of mitochondrial mechanism (mitophagy) for cancer treatment. Herić, Amir; Silajdžić, Amar; Zubčević, Tarik (2024). 18(1) 064–072.

  Mitochondrial organelles are crucial organelles for the energy supply of the whole cell. Also, mitochondria are beneficial for the production of ATP, a byproduct of the stabilization of nutrients in the TCA cycle, and FADH and NADH are reducing equivalents. Defects in mitochondria impair the energy supply, metabolite production, and redox reactions. Also, a crucial point for cell survival is to maintain mitochondrial quality rather than quantity. Qualitative mitochondria are required to produce the proper amount of ATP, degrade p53, and decrease reactive oxygen species (ROS) production. All of these factors lead to mitochondrial dysfunction. Dysfunctional mitochondria are „eaten“ by autophagosomes through the process of mitophagy. Mitophagy is crucial since it prevents the build-up of poorly/affected mitochondria, and prevents excess production of ROS and mtDNA mutation. Also, mitophagy shows positive effects on cancer, since mitophagy promotes pro-apoptotic signals for cancer stem cells (CSC). Due to all the advantages of mitophagy, this organelle can be used as a beneficial assistant for chemotherapy in cancer treatment. The authors of these papers provide a pathway for using mitophagy combined with cancer treatment. This claim is confirmed within the paper, with tables provided. Our results show the importance of mitophagy in human organisms and its importance in cancer.
• Study of petrol degrading bacteria and screening for biosurfactants. Shah, Pratibha Jinesh; Israni, Jaya Naresh; Lokhandwala, Insiya Zulfeqar (2024). 18(1) 073–078.

  Petroleum-based products when mixed with soil, air and water can lead to environmental pollution which can be dangerous for humans. In the current study, soil samples from the petrol unloading area of a petrol pump were collected and nine isolates of petrol degrading bacteria were isolated from the soil by enrichment technique using Bushnell and Hass media. The isolated bacteria could degrade up to 5% petrol and the best degraders were chosen after evaluating their cell mass when grown in the presence of petrol. The percentage of petrol degraded after different intervals of incubation was compared using a UV-vis double beam spectrometer at 228 nm. It was found that the two bacteria - Pseudomonas aeruginosa and Burkholderia cepacia degraded petrol 94.96% and 94.74%, respectively, by day 15 of incubation. The percentage degradation gradually decreased by day 20. Both bacteria were also screened for the production of biosurfactants through haemolysis. It was found that both the bacteria could produce biosurfactant along with them being a potent petrol degrader.
• Armamentarium of wart control by using Allium sativum, malus and pumila mill. MALARVIZHI, G.; V, SUJAYA. (2024). 18(1) 094–101.

  Human papillomavirus (HPV) infection is the cause of warts. The virus induces the top layer of skin (epidermis) to create an overabundance of the hard protein keratin. A wart has a harsh, gritty texture due to the excess keratin. Skin warts are microscopic growths brought on by a viral infection. It can be treated with over the counter medications. These are usually rough, tiny growths that can develop on the hands, feet, or genitalia, among other regions of the body. Garlic extract, which has a wide range of possible health advantages, is made from garlic cloves. It is a metabolite-rich, disease-preventive nutraceutical spice that is enhanced with polyphenols and organosulfur. It contains chemicals with antibacterial and antioxidant effects, including allicin. Because apple cider vinegar extract has so many potential benefits, it is frequently used for skin care. Because it lowers oil and bacteria on the skin, it has been used to treat acne. By reducing inflammation, it might also be beneficial for skin disorders like eczema.
• Atlas der KI: die materielle Wahrheit hinter den neuen Datenimperien Crawford, Kate (2024). C.H. Beck, München.

  Wir tendieren dazu, künstliche Intelligenz als eine wundersame und körperlose Form der maschinellen Klugheit zu betrachten. Von der preisgekrönten Wissenschaftlerin Kate Crawford lernen wir hingegen, dass KI in Wahrheit weder künstlich noch intelligent ist, sondern in ihrer materiellen Wirklichkeit auf Ressourcenausbeutung und Machtkonzentration hinausläuft.
• Accuracy in placing oral cuffed endotracheal tube to correct depth in Indian adults based on conventional guidelines. Mandal, Debjyoti; Ghosh, Tirtha Ratan; Pahari, Subrata (2024). 18(1) 102–106.

  Background & Aims: Precise positioning of oral Endotracheal tube (ETT) anytime is difficult however if attained will ease complications of its misplacement. The accuracy in positioning oral cuffed ETTs to the correct depth in Indian adults following conventional guidelines was sought for. Methods: This study was conducted upon 240 adults ageing 20 to 60 years of both sex, who required endotracheal intubation at operation rooms or already intubated due to any reason admitted in CCU of BSMC&H, Bankura, West Bengal, excluding patients with hemodynamic instability and upper airway deformities. Oral ETT intubation was performed and ETT fixed at incisors following conventional guidelines. ETT tip to Carina distance was measured with fiberoptic bronchoscope thereafter. The power of study was kept at 0.95. Obtained data were evaluated with descriptive and inferential statistical tests by Microsoft Excel 2016. Results & Conclusions: Only 60% (n=144) of ETTs were found to be accurately positioned. In the rest 40% (n=96) of misplaced ETTs, the majority (91%, n=87) were placed too deep. Predetermined fixing the ETTs at 21 cm and 23cm mark in females and males respectively leads to deep placement in 36% of them. Hence, we can declare that securing ETT at midline according to the conventional guidelines doesn’t match our Indian people.
• AI Strategy Formulation Across Various Game Genres - A Literature Review. Chan, Cheuk Man; Haralick, Robert (2024). 55(1) 92–100.

  Microblogging is one of the latest Web 2.0 technologies. The key elements are online communication using 140 characters and the fact that it involves “following” anyone. There has been a great deal of excitement about this in recent months. This paper reports on a research study that was carried out on the use of a microblogging platform for process-oriented learning in Higher Education. Students of the University of Applied Sciences of Upper Austria used the tool throughout their course. All postings were carefully tracked, examined and analyzed in order to explore the possibilities offered by microblogging in education. It can be concluded that microblogging should be seen as a completely new form of communication that can support informal learning beyond classrooms.
• Affiliate Marketing Jobs owner (https://zeeblogger.com/index.php/5-companies-giving-affiliate-marketing-jobs-with-high rates/, ed.) (2024). online marketing.
• Intelligent Efficient Routing and Localization in the Underwater Wireless Sensor Network to Improve Network Lifetime. Vinayprasad (2024). (Vol. 16)
• Pneumonia Risk, Antipsychotic Dosing, and Anticholinergic Burden in Schizophrenia. Luykx, Jurjen J.; Correll, Christoph U.; Manu, Peter; Tanskanen, Antti; Hasan, Alkomiet; Tiihonen, Jari; Taipale, Heidi (2024). 81(10) 967.
• Heterogeneity in Antidepressant Treatment and Major Depressive Disorder Outcomes Among Clinicians. Rathnam, Sarah; Hart, Kamber L.; Sharma, Abhishek; Verhaak, Pilar F.; McCoy, Thomas H.; Doshi-Velez, Finale; Perlis, Roy H. (2024). 81(10) 1003.
• Differential Outcomes of Placebo Treatment Across 9 Psychiatric Disorders: A Systematic Review and Meta-Analysis. Bschor, Tom; Nagel, Lea; Unger, Josephine; Schwarzer, Guido; Baethge, Christopher (2024). 81(8) 757.
• Mastering the Essentials: Core Topics in Clinical Research Courses. dongare, kajal (2024).
• Advancements and challenges in digital health implementation in India: A comprehensive literature review. Lad, Rahul A.; Padroo, Bhawna Sharma (2024). 18(1) 205–208.

  Digital health has emerged as a promising solution to address healthcare challenges in India, offering innovative tools and technologies to improve access, delivery, and outcomes. This comprehensive literature review provides a detailed analysis of the current state of digital health implementation in India, exploring advancements, challenges, policy initiatives, and future prospects. Drawing upon a wide range of academic literature, government reports, and industry publications, this paper examines key themes such as telemedicine, mobile health (mHealth), electronic health records (EHRs), health information exchanges (HIEs), government initiatives, challenges, and future directions in digital health. By synthesizing existing research, this paper aims to provide insights into the opportunities and barriers associated with digital health in India and offers recommendations for policymakers, healthcare providers, and stakeholders to leverage digital technologies effectively to improve healthcare delivery in the country.
• Monocyte to HDL cholesterol ratio and smoking are predictors of epicardial fat tissue thickness. Yılmaz, Mücahid; Mirzaoğlu, Çetin (2024). 18(1) 012–020.

  Objective: Smoking stimulates lipid accumulation and causes non-alcoholic fatty liver disease. Epicardial Fat Tissue (EFT) resides between the visceral pericardium and myocardium. The aim of this study was to determine whether if smoking may accumulate Epicardial Fat Tissue thickness (EFTt). Material and methods: 266 smoking and 500 non-smoking subjects were included in the study. The subjects were chosen to be healthy individuals, without any cardiovascular/systemicdisorders or risk factors for atherosclerosis (except hyperlipidemia). Transthoracic echocardiography (TTE) was applied to all subjects, and EFTt was measured in both diastole and systole (EFTtd and EFTts respectively). Results: EFTtd, EFTts, low-density lipoprotein cholesterol, triglyceride, and monocyte to the HDL cholesterol ratio (MHR) values were found to be significantly increased in the smoking group when compared to the non-smoking group. Pearson’s correlation analyses revealed that EFTtd and EFTts were related to pack.year, low-density lipoprotein cholesterol, triglyceride, MHR, BMI, and age. Linear regression analysis results showed that smoking, pack.year, BMI, age, and MHR were independent predictors of EFTtd, EFTts. Conclusions: The study results showed that smoking increases the EFTtd and EFTts. Smoking and MHR were independent predictors of EFTt. Evaluating blood parameters together with EFTt may guide primary prevention in smokers.
• Male urethral stricture disease in a tertiary hospital in Port Harcourt, Nigeria: a five-year review of features, management and outcome. Sapira, Monday Komene (2024). 18(1) 214–226.

  Introduction: The aim is to assess the early impact of the current increased use of transurethral endoscopic procedures and emerging technologies on the management of urethral stricture disease (USD) in adult males at the University of Port Harcourt Teaching Hospital (UPTH), Nigeria. Material and Methods: The design of the study was cross-sectional and descriptive. Secondary data of patients treated between 01/6/2017 to 30/6/2022, with confirmed diagnosis of USD were used. Their registration numbers were used to access their records at the Health Records Department of the Hospital. Information obtained included sociodemographic data, aetiology, clinical features, types, sites and diagnostic tests of male USD, , uroflowmetry, urethral, and abdominopelvic ultrasonography, cystourethrography results, treatment methods, outcomes, complications and co-morbidities of USD. Data obtained were analyzed with simple statistics and presented. Results: Of 10,450 Urology patients 245 had USD. Data on 224 were found and analyzed. Their age profiles in years were mean, 45.7±18.6; age range 10-95. Married were 174 (77.68%). Urethral strictures were post inflammatory 126(56.25%); post traumatic 43.75%; bulbar,73(32.59%); bulbomembranous23.22%; posterior urethral 52(23.21%); penile 34(15.18%); and pan urethral 13, (5.18%). At presentation, 105 (46.88%) were hypertensive; 40.2% had UTI with Gram-negative bacilli. Recurrence of strictures occurred 6 months to one year after DVIU; 2 months to 6 years after urethroplasty. Non-compliance with schedules and follow-p occurred in 111 (49.55%) patients. Conclusion: USD prevalence was 24/1000 urology patients. UTIs were probably healthcare and prolonged catherization associated. Screening/review of service processes warranted. Lack of validated tools for measurement of outcome or dependent treatment variables made comparative studies unrealistic.
• Some aspects of clinical trial of the drug “Vetmicoderm”. V, Ogloblina M.; V, Bushueva I.; P, Martynyshyn V.; M, Hunchak V.; V, Parchenko V. (2024). 18(2) 001–004.

  Our aim was to conduct some clinical trials of the drug «Vetmikoderm» and compare its effectiveness with the well-known agent «Triosan». Clinical trials to determine the therapeutic effectiveness of the drug «Vetmikoderm» were carried out at the veterinary clinic «BEST» (Zaporizhzhia) on two groups of dogs, formed by gradual recruitment (based on the owners' referral to the clinic). To determine the etiological factors contributing to the development of dermatosis, we conducted a study of skin microflora. The sensitivity of microorganisms and fungi to the action of the «Vetmikoderm» preparation was determined by the disc-diffusion method. In the process of diagnostic research, including microbiological studies, it was established that conditionally pathogenic microflora from affected areas of dogs' skin was represented by both microorganisms and fungi. At the same time, fungi prevailed in the microbiocenosis of the selected skin samples. It is worth noting that «Vetmikoderm» has a better fungicidal effect, while «Triosan» is evidently more effective in treating dermatoses with predominantly microbial contamination. It has been proven that the combined use of both drugs has a better influence on the recovery process in animals.
• Inflammatory Patterns in the Prostate Gland and Serum Cytokine Activities in Primary Adenocarcinoma of the Prostate in Port Harcourt, Nigeria. Ogbonnaya, Ukamaka Chinelo; Sapira, Monday Komene (2024). 18(1) 227–232.

  Introduction: Chronic inflammation and pro-inflammatory cytokines such as (1L-6 and TNF-α) have been implicated in prostate carcinogenesis and metastasis. This study aims to evaluate serum concentrations of IL-6 and TNF-α, and to determine their association with clinicopathological patterns of prostate cancer in affected patients. Materials and Methods: Ninety (90) patients with histologically diagnosed prostate cancer (PCa), treated at the Urology Division of the University of Port Harcourt Teaching Hospital (UPTH), Nigeria were involved in this study. The enzyme-linked immunosorbent assay (ELISA) technique was used to assay cytokines (IL-6 and TNF-α), and serum PSA. Gleason Scores were categorized as well differentiated (GS of ≤ 6), moderately differentiated (GS = 7), and poorly differentiated (GS 8-10). Results were analyzed with IBM SPSS version 20.0. Pearson’s correlation test was used to determine the correlation between the cytokines (IL-6 and TNF-α) and Gleason Scores. Results: The modal age group with PCa was 60-69 years. The mean age of patients was 68.788.26 years, and the mean serum PSA 93.2478pg/ml. Serum levels of IL-6 and TNF-α were 8.0pg/ml, 11.2pg/ml and (27.0±26.4pg/ml) respectively. Forty-six subjects had poorly differentiated PCa (GS 8-10); 17 moderately differentiated (GS 7); and 27 well differentiated (GS ≤ 6). Mean serum levels of IL-6, TNF-α and PSA (113.1ng/ml) were raised and found highest in those with poorly differentiated PCa. Conclusion: The observed correlation was positive but weak. The patients might have commenced undeclared anti-inflammatory drugs that depressed inflammation. However, a larger sample size would probably confirm the prognostic value of IL-6 and TNF-α in PCa subjects.
• Traditional medical practice on Primitive Nooka Dora tribes, Alluri Sitaramaraju District, Andhra Pradesh. Aishwarya, Padi; jedidiah, Dokka Joseph; Prasad, S. R. N. Vamsi Vara; Snehith, Pamula Joy; Padal, S. B. (2024). 18(1) 363–367.

  An ethnomedicinal survey was carried out in HukumpetaMandal, AlluriSitaramaraju District, Andhra Pradesh, India. For documentation of important ethnomedicinal plants and information from local community about their medicinal uses. The traditional knowledge of primitive Nooka Dora tribe traditional uses was collected through questionnaire and personal interviews during field trips. The identification and nomenclature of the listed plants were based on the Flora of Andhra Pradesh. A total of 49 plants species belong to 47 genera and 37 families were identified by taxonomic description and locally by ethnomedicinal knowledge of people existing in the region.
• Internal medicine consults within the emergency department: A workflow intervention to match workforce with workload. Montague, Steven J.; Curran, Scott J.; Maracle, Amanda C.; Smith, Christopher A. (2024). 18(1) 368–375.

  Background. Emergency departments (ED) are increasingly overcrowded, exacerbated by patients awaiting consultations and inpatient beds. Internal Medicine (IM) is the most consulted specialty service from the ED. Patients experience long delays after being consulted to Internal Medicine (IM). Objective. Decrease these delays by improving the IM consult process. Methods. A three stage process was designed. First: Analysis of the IM consult workflow over a 27-day period to identify the longest delays. Then implement a data-driven intervention. Second: Quantitatively assess the intervention by comparing three-month periods Pre-Intervention (Time A) with Post-Intervention (Time B). Third: Qualitatively assess the intervention by surveying residents. Results. The first stage included 398 consults. The longest delays were awaiting bed availability post admission order completion (mean 19.5 hours) and awaiting the initial junior resident assessment (mean 3.6 hours). This assessment delay significantly increased during busy shifts. The intervention involved the addition of an extra IM resident during the busiest four hours of the day. The second stage compared 1162 patients from Time A with 1263 patients from Time B. There was no significant change in assessment times post-intervention. However, there was an 8% increase in consult volume in Time B as compared to Time A. The third stage captured 100% of the 23 senior residents. Overall, residents reported the change as beneficial to themselves and the patients. Conclusions. For patients consulted to IM in the ED, inpatient bed availability contributed to the largest delay to leave the ED. Increasing IM resident staffing during peak hours did not decrease time to complete consults. However, increased IM resident staffing was perceived as beneficial to both residents and patients.
• Victim Care or Defendant Rights? Assessing Public Attitudes towards Special Measures Designed to Support Vulnerable Witnesses at Trial. Metson, Jessica; Willmott, Dominic (2024). 13(4)

  The introduction of ‘special measures’ within England and Wales (i.e., provisions for vulnerable and intimidated witnesses at court) marked a significant change in legal tradition and trial procedures such that victim and witness care was repositioned as a primary concern alongside the longstanding rights afforded to defendants. As public perceptions towards the legitimacy of criminal justice procedure remain a key concern among legal scholars and social scientists, this study aimed to examine individual differences in attitudes held towards the rights afforded to complainants and defendants within English courts. Adopting a cross-sectional study design, 114 UK adults were recruited to take part in an online survey. Questions centered around the importance of providing adequate witness care whilst protecting defendants’ rights to a fair trial. A new measurement tool was developed to allow these attitudes to be systematically assessed and understood, termed the Attitudes Towards Vulnerable Victims Scale (ATVVS). Results indicate that respondent age, gender, level of education, and belief in a just world are important determinants of public support for the use of special measures at trial as well as perceptions towards complainant and defendants’ rights. Taken together, findings indicate that misconceptions about vulnerable victims appear to underlie a lack of support for the use of special measures.
• Development of seat mats for drivers using Aloe vera. Kavitha, V; Nivetha, T Saru (2024). 18(1) 376–380.

  The automotive industry is continuously evolving to enhance driver comfort and safety. One crucial aspect of driver comfort is the seating experience, which plays a significant role in reducing fatigue and enhancing overall well-being during extended journeys. This abstract introduces a novel approach to seat mats for drivers, incorporating Agave Americana, commonly known as the American Century Plant, as a sustainable and effective material. The proposed seat mats for drivers are designed to offer a blend of durability, breathability, and comfort. Agave Americana fiber is known for its exceptional strength, making it an ideal candidate for a material that can withstand the rigors of daily use in a vehicle. Furthermore, its natural breathability helps regulate temperature and moisture, ensuring a more comfortable seating experience during long drives. Ultimately, the adoption of Agave Americana-based seat mats has the potential to improve driver well-being, reduce the environmental footprint of automotive manufacturing, and contribute to the broader shift toward sustainable materials in the industry.
• Comparison of platelet count by automated hematology analyzer and peripheral blood smear in thrombocytopenic patient. Prajapati, Ajeet Kumar (2024). 18(1) 381–387.

  Platelet count estimation is one of the common as well as important laboratory investigations to diagnose many diseases like dengue, malaria etc. Different methods for platelet estimations are automated haematology analyzer, peripheral blood smear examination method etc. Most common causes of inaccurate platelet count by automated analyser are the presence of giant platelets, platelet clumps etc. leading to erroneous result like false low platelet count etc. We aimed to compare platelet count estimation by automated haematology analyzer and the peripheral blood smear examination in thrombocytopenic patients. A comparative cross-sectional study was conducted on 100 blood samples of patients which came thrombocytopenic on automated haematology analyzer. Each case was also analyzed by peripheral blood smear examination and compared with its corresponding automated haematology platelet count value. Our study included 63% males and 37% females, with the mean age of 38.8 years. Most of the patients belonged to the age group of 30-40 years (34%). The mean platelet count on automated analyzers was 85.46 ± 38.81 x 103/uL whereas on peripheral smear was 92.13 ± 38.30×103/uL with a significant difference between the two groups (p-value <0.0001).Pseudo-thrombocytopenia was observed in 10% of patients, with giant platelets observed in 29% of the cases on blood smear. In view of false low platelet count by automated analyser, we concluded that manual examination by peripheral blood smear examination should always be considered whose platelet count is low by automation.
• Optimization and evaluation of bilayer tablet of probenecid. Wagh, Gopal Gajanan; Mahajan, Vinay; Sharma, Ramakant; Gupta, Revathi A. (2024). 18(1) 388–398.

  The main objective of my research work is to develop a bilayer tablet of Probenecid, in which one layer is immediate layer for immediate action and second layer is the sustain release layer for maintaining the dose of the drug. Probenecid is frequently administered up to 3 times in a day. So, the reducing dosing frequency by sustained release tablet.
• Identification and fatty acids composition of Xestospongia vansoesti and Aaptos suberitoides. Al-Talafha, Ali M.; Al-Mobideen, Omar Khaled (2024). 18(1) 399–407.

  Taxonomic identification is the most significant step in any research, and this is especially true of the sponge fauna. Two marine sponges were identified based on their morphology, skeleton, and spicules characteristics and the fatty acid composition was also studied for Xestospongia vansoesti and Aaptos suberitoides. In both species, the main saturated acids were 16:0 and 18:0. Saturated fatty acids C14-18 of iso /anteiso-structure were detected in both species with different percentages. The positional isomers of octadecenoic acid were the most common in both species with 6.78 % in Xestospongia vansoesti and 5.3% in Aaptos suberitoides. Two demospongic acids C25:2 Δ 5, 9 and C26:2 Δ 5, 9 were detected in both species and the percentage of 5,9-Hexacosadienoic acid in Aaptos suberitoides is high with 7.26% of the total fatty acids content. The characterization of 5,9-pentacosadienoic acid was achieved based on the MS spectra to confirm the presence of demospongic acids in both species.
• Delving into artemisinin’s shadow: Insights from a unique case of artesunate – resistant complicated falciparum malaria. Poojitha, Puchakayala Sai; Soren, Bhimasen; Sudheer, Kanugula (2024). 18(1) 408–412.

  The emergence of drug-resistant malaria poses a formidable health challenge in emerging nations such as India. The ineffectiveness of the medicine artemisinin, which is essential for treating malaria, will quickly undermine the treatment and outlook for malaria patients. If, following a complete course of therapy with Artesunate Combination Therapy and without any instances of vomiting or diarrhoea, there is no clinical or parasitological improvement in the patient within 72 hours, resistance may be considered. Reports of artemisinin-resistant Plasmodium falciparum malaria are rare in the southern regions of India. This article details a case of rare Artesunate-resistant complex falciparum malaria.
• Hazard functioning modeling for dextrose fluids associated hemodilution; Cox-regressional analysis for patients’ Hematocrit Hemoglobin Ratio. Alshawabkeh, Amani Daoud; Alqatarneh, Ali Kathm Mohammad Ali (2024). 18(2) 005–015.

  Aims: This study looks at the cox-regressional relationships between hematocrit to hemoglobin ratio (HHR) and a group of outcomes of interest (cOI). These outcomes include death from any cause, acute myocardial infarction, stroke, and severe dilutional hyponatraemia incidence. Additionally other outcome of interest in this study will be prolongation of admission days, infection rate, acute kidney injury, and mandating the transition to the critical unit and mechanical ventilation intubation. The study also will investigate the performances of the tested ratio and will explore their sensitivity, specificity, and accuracy indexes. Methods: Between 2018 and 2022, a retrospective study was conducted at the King Hussein Medical Centre in Amman, Jordan, involving 926 patients. The study aimed to determine the potential risk of dilution of red blood cells in circulation caused by dextrose-containing fluids in patients with chronic kidney disease. The study aimed to determine the ideal threshold levels of the investigated ratio (HHR) to enhance clinical outcomes and safety margins, particularly in patients with severe renal impairment or chronic kidney disease in a hospital setting. The study included patients with fluctuating kidney function, renal replacement therapy, uncontrolled diabetes, and conditions necessitating specific fluid regimens. The study used binary logistic regression and cox-regression proportional hazard modelling to examine the correlation between the hematocrit to haemoglobin ratio and the composite outcomes of interest (cOI) in patients from Jordan. The findings suggest that higher cOI likelihood indicates a more advantageous condition, while lower values suggest a less advantageous condition. Results: A retrospective study at the KHMC in Amman, Jordan, involved 1306 patients from 2018 to 2022. The study focused on the hematocrit to haemoglobin ratio (HHR) and achieved correct classification rates of 70.8%. The best HHR was 2.555:1, with a 42.8% chance of occurring at this level. Cox-Regression Proportional Hazard Modelling revealed a censored percentage of 83.4% in HHR>2.555 stratum and 51.5% in HHR≤2.555 stratum. The study found a high percentage of HD patients processed in the analysis. Conclusion: Intravenous dextrose fluids associated hemodilutional state is linked to all-cause mortality in admitted medically and surgically patients and cardiovascular death. Low ratio increases the risk. Factors such as malnutrition and kidney function loss contribute to prognosis. Future studies should focus on mechanistic pathways, optimal targets, age, and sociodemographic factors.
• Precision healthcare analytics: Integrating ML for automated image interpretation, disease detection, and prognosis prediction. Ijiga, Amina Catherine; Igbede, Monica Ajuma; Ukaegbu, Chukwunonso; Olatunde, Timilehin Isaiah; Olajide, Frederick Itunu; Enyejo, Lawerence Anebi (2024). 18(1) 336–354.

  This review paper provides an overview of precision healthcare analytics, focusing on the integration of machine learning (ML) techniques for automating image interpretation, disease detection, and prognosis prediction across various medical imaging modalities, including X-rays, MRIs, and CT scans. Drawing upon existing literature and empirical evidence, we assess the impact of ML-driven automated image interpretation on diagnostic accuracy, highlighting its superiority over traditional methods. Additionally, we examine the effectiveness of ML algorithms in disease detection, emphasizing their potential for early intervention and improved patient outcomes. Furthermore, we explore the prognostic capabilities of ML-based models in forecasting disease progression and guiding treatment strategies. Through a comprehensive synthesis of research findings, we identify key factors influencing the performance of ML algorithms in healthcare applications and discuss strategies for addressing challenges related to data quality, interpretability, and scalability. By critically evaluating current trends and advancements in precision healthcare analytics, this review aims to provide insights into the potential benefits and limitations of ML integration in medical practice, contributing to the ongoing discourse on enhancing patient care and healthcare delivery.
• Pathogenicity islands in bacteria of upper respiratory tract infection. Daamee, Rawaa B. J. Al; Raheema, Rana H.; Altameemi, Qasim Dawood Yasir; AL-Naqeeb, Maan M.N. (2024). 18(2) 016–023.

  Children's upper respiratory tract infections (URTIs)—infections of the upper respiratory tract without symptoms of pneumonia—represent a significant socioeconomic and epidemiological issue. The study of microbial pathogenicity, which is a complex multifactorial process complicated by the coordinated activity of genetic regions linked to virulence and resistance determinants, has accelerated due to increased awareness of infectious diseases in humans caused by microbial pathogens. Pathogenicity islands and resistance islands are essential to the evolution of pathogens and seem to work in tandem during the bacterial infection process. While pathogenicity islands encourage the development of illness, Additionally, pathogenicity islands are part of a vast array of genomic islands that play a vital role in the transmission of bacterial genes. They encode essential characteristics such as virulence, antibiotic resistance, and other supplementary functions.
• Analysis of biological organic extract of plants in suppressing aphid (Myzus persicae) infestations. Khan, Rahmah; Paul, Newton (2024). 18(2) 024–032.

  Myzus persicae commonly known as the peach-potato aphid, poses a significant threat to agricultural productivity, particularly in potato cultivation, where infestations lead to substantial yield losses and quality degradation. In this study, we investigated the potential of botanical extracts from neem (Azadirachta indica), clove (Syzygium aromaticum), black pepper (Piper nigrum), and bay leaf (Laurus nobilis) in controlling Myzus persicae infestations. Experimental trials were conducted to assess the mortality effects of these botanical extracts on Myzus persicae populations. Results revealed that neem extract exhibited the highest mortality effect, with an impressive 97.7% mortality rate. Clove and black pepper extracts followed closely, demonstrating mortality rates of 92.2% and 77.7%, respectively. In contrast, bay leaf extract exhibited the least mortality effect, with only 48.8% mortality observed.
• Screening of phosphate solubilizing Aspergillus spp. from soil samples. L., Barate D.; R., Gawai D. (2024). 18(2) 033–040.

  Phosphorus (P) is a naturally existing element crucial for plant growth among the 17 essential elements. It's integral to various biomolecules like nucleic acids, coenzymes, phosphoproteins, and phospholipids, playing key roles in cellular processes and structural integrity. Its presence is fundamental for sustaining healthy plant growth and ecosystem balance. Rhizosphere soil samples from medicinal plants at Shree Shivaji College Akola were collected aseptically. Phosphate Solubilizing Fungi (PSF) were isolated using Pikovskya’s agar medium, characterized microscopically, and screened for phosphate solubilization potentials. % Solubilization Efficiency was determined, and quantitative estimation of phosphate solubilization was conducted by ammonium molybdate method by using KH2PO4 as standard for determination. Fourteen Aspergillus spp. isolates from soil were screened for phosphate solubilization on PVK medium. Results showed varied solubilization indices and efficiencies across different time intervals, with pH changes observed during solubilization. Optical density measurements provided insights into concentration variations among isolates.
• Effect of methanol stem bark extract of Ochna schweinfurthiana (Ezeata) on liver enzymes in Wistar rats. Ifemenam, Kosi Emmanuel; Nwozor, Cornelius Maduabuchi; Adinnu, Dennis Chukwujekwu; Iwuamadi, Cynthia Ebelechukwu; Ezeh, Anthonia Kanayo (2024). 18(2) 041–048.

  The effects of methanol stem bark extract of Ochna schweinfurthiana were studied using Wistar rats. Twenty (20) experimental animals (Wistar rats) were randomly grouped into four groups of 5 rats each. They were allowed to acclimatize for 2 weeks. Rats in group A served as the control and were fed with rat feed and water only, rats in groups B to D were fed with normal rat feed, water and were fed with different doses of Ochna schweinfuthiana extracts at 200, 400 and 800mg/kg respectively for 4 weeks. The Animals were sacrificed under anesthesia after the experiment and liver was harvested and the weights were taken. Blood samples were collected for liver enzymes estimation: aspartate transaminase (AST), alkaline phosphate (ALP) and alanine transaminase (ALT) were checked. The extract proved to be hepato-protective as there were significant decrease in the liver function enzymes (AST, ALT, and ALP) P<0.05. This may indicate some hepato-protective effect of Ochna schweinfurthiana.
• Alzheimer Disease. Shaikh, Uzer Altaf; Shinde, Sanket P. (2024). 18(2) 049–057.

  Alzheimer's disease (AD) is typified by memory deficiencies that worsen with time, along with cognitive and behavioral abnormalities that eventually result in dementia. AD is one of the most difficult diseases to treat because of its prevalence, high cost of care, effects on patients and caregivers, and lack of mechanism-based therapies. The malfunction and loss of neurons in particular circuits and locations, especially in the populations of nerve cells supporting memory and cognition, causes the AD condition.The neuropathology of AD is characterized by intracellular and extracellular protein aggregation accumulations. In the neuronal perikarya and dystrophic neurites, abnormally phosphorylated tau forms paired helical filaments (PHFs) that combine to form neurofibrillary tangles (NFTs). The extracellular deposition of β-pleated assemblies of Aβ peptide, which result in widespread and neuritic senile plaques, is the second pathogenic hallmark.
• Screening and molecular identification of l-asparaginase producing bacteria with ansB gene from sewage water. Tiwari, Shreya; Mehta, Rakesh; Gothalwal, Ragini; Pandey, Laxmikant (2024). 18(2) 058–064.

  Enzymes are vital biocatalysts facilitating biochemical reactions in organisms, playing pivotal roles in both biological systems and numerous industrial applications. This study focuses on the isolation and screening of asparaginase-producing bacteria from sewage water samples in Bhopal City. A modified M9 media, supplemented with asparagine and phenol red, was used to isolate asparaginase-producing bacteria. Out of the ten samples, seven exhibited asparaginase activity. Two bacterial strains, identified as Bacillus tropicus (S-1) and Priestiaveravalensis (S-2), were found to harbor the ansB gene. Sequence analysis revealed a 96.52% and 95.09% resemblance to Bacillus tropicus MCCC 1A01406 and Priestiaveravalensis strain SGD-V-76, respectively. These findings highlight the potential of these bacterial strains in producing L-asparaginase, emphasizing their significance in pharmaceutical applications, particularly in cancer treatment.
• Floating drug delivery systems: A review. Gadge, Abhishek Ravindra; Lamkhade, Ganesh Jayram; Vishe, Sayali Ulhas; Varpe, Mayur Maruti; Kazi, Moin Mehboob (2024). 18(2) 065–073.

  To boost medication bioavailability, target the stomach mucosa, and lengthen gastric residence time, a multi-unit oral floating drug delivery system was created. Due to their potential to enhance drug delivery, floating tablets have become more significant in pharmaceutical formulation. In the upper GIT, where the environment is acidic, tablets absorbs poorly. The bioavailability shows 50% when administer orally. An H2-receptor antagonist called tablets is frequently prescribed to treat gastrointestinal issues brought on by excess stomach acid. With the right excipients and polymers, floating tablets are meant to float on the contents of stomach Over an extended length of time, extending medication release and bioavailability. This review examines the advantages, disadvantages, and in vitro or in-vivo evaluation of famotidine floating tablets with an emphasis on their potential to improve treatment outcomes and patient compliance.
• Transthoracic echocardiography evaluation of double outlet left ventricle: Unique case report and review of literature. Mehrotra, Akhil; Siddiqui, Faiz Illahi; Shakya, Ujala; Shaban, Mohammad (2024). 18(2) 074–090.

  Double-outlet left ventricle (DOLV) is a rare cardiac malformation in which both great arteries originate from the morphological left ventricle. DOLV is associated with high mortality, generally due to heart failure, myocardial infarction, or aortic thrombosis. With surgery, the 5-year survival rate is estimated at 70%–75%. Most patients will continue to present with residual cardiac anomalies, such as aortic or mitral valve regurgitation, arrhythmias, or hypertension. We are reporting a complex case of cyanotic congenital heart disease in a 5 month old female infant suffering from DOLV, who presented to us with recurrent chest infections and bluish colouration of skin.
• Evaluation of diuretic activity of hydroalcoholic extract of Leptadenia pyrotechnica in rats. Sharma, Heena; singh vaghela, Jai; Suthar, Payal; mali, Mohak (2024). 18(2) 091–101.

  In traditional Indian medicine, the whole plant of Leptadenia pyrotechnica (Asclepiadaceae) is said to have a strong diuretic effect. The aim of this study was to evaluate the diuretic potential of the hydroalcoholic extract of Leptadenia pyrotechnica (HALPE) in rats. Group I, control (0.5% CMC saline, 10 ml/kg, b.w.), group II, furosemide (10 mg/kg b.w.) as a standard drug, and different concentrations of L.P. (100, 200, and 400 mg/kg b.w.) were administered intraperitoneally (n = 5 per treatment group) to hydrated rats, and their urine output was monitored at 6 h, 12 h, and 18 h after drug administration. The diuretic effect of the extract was highly significant compared to control animals. Halpe at a dose of 400 mg/kg shows a significant increase in urine volume with increased urine output. This study suggests that the active component of L.P. had a diuretic effect similar to that of furosemide. These results confirm the traditional use of Leptadenia pyrotechnica as a diuretic agent. Since ancient times, medicinal plants, sometimes called herbs, have been used in various traditional medical procedures. Leptadenia pyrotechnica is a plant commonly known as the chimp. It is traditionally used in rural areas for the treatment of many diseases, such as antifungal, antibacterial, anticancer, antioxidant, wound healing, anthelmintic, atherosclerosis, hypolipidemia, diuretic, diabetes, and hepatoprotective. In rural areas, this plant is also used as medicine and as a vegetable. First, the plants are dried and turned into powder, which is then used as a paste for ringworm, antifungal, wound treatment, and new plants for many other diseases.
• An in-depth review of thalidomide’s basic moieties. Vishe, Sayali Ulhas; Lokhande, Rahul Prakash; Wagh, Sayali Adinath; Pathan, Saniya Dastagir; Pathan, Samrin Rafik (2024). 18(2) 102–109.

  Thalidomide, also referred to as N-phthalimido glutarimide, was initially made available as a sedative by Chemie Grunelthal GmbH in West Germany in 1957. Thalidomide's chemical structure primarily consists of two rings: the phthalimide ring and the glutarimide ring. Although small substitutions in one or both rings might be tolerated without a reduction in toxicity, both of these groups were necessary for embryopathic action. A cyclic chemical structure that is a component of thalidomide is the phthalimide ring. The phthalimide ring is thought to contribute to both the teratogenic (causes birth defects) and some therapeutic aspects of the medication. Another cyclic structure seen in the chemical makeup of thalidomide is the Glutarimide Ring. The pharmacological characteristics of thalidomide are also connected to this portion of the molecule. Based on their activities and structural connections, this review study gives an overview of the interaction between phalidimide and the glutarimide ring for teratogenicity of the thalidomide type. Understanding how thalidomide interacts with the human body, both for its intended therapeutic effects and its negative side effects, especially when taken during pregnancy, is important given the combination of these rings in the drug's chemical structure.
• Impact of the period of anti-pandemic measures during the COVID-19 pandemic on the sexual life of adolescents and young adults in Slovakia. Verešpej, Šimon (2024). 18(1) 355–362.

  The aim of the research is to highlight the impact of the period of anti-pandemic measures during the COVID-19 pandemic on the sexual life of adolescents and young adults in Slovakia. At the beginning of the study, 8 participants were obtained through voluntary and random selection, with whom interviews were subsequently conducted to gain insight into their experiences regarding the pandemic's impact on their sexual life. The interviews were then analysed using narrative analysis. We focused on 11 subcategories: frequency of sexual activities, space for engaging in sexual activities, use of sex, use of masturbation and pornography, sexual communication, emotions associated with sexual activities, changes in sexual self-confidence, changes in sexual preferences, factors influencing sexual life, self-assessment of the pandemic's impact on sexual life, sexual life post-pandemic.
• Mapping the changing face of cross-examination. Jackson, J; Doak, J; Saunders, C; Wright, D; Cooper, D (2024).
• Leukemia its origin, types, risk factors and survivorship. Jaiswal, Gayatri; Dubey, Rajani; Prajapati, Krishna Kumar (2024). 18(1) 283–292.

  Leukemia cancer; Feline leukemia virus (FeLV); CAR-Natural Killer and CAR-macrophages; TPMT and NUDT15 genes; Thiopurines.Leukemia is a cancer of the body’s blood forming tissues such as bone marrow and the lymphatic system. It is most common cancer in the children but mostly occur in adults.The general symptoms in leukemia cancer are appetite and headaches, and red patches on the skin of patients.The hematopoietic stem cell help to regenerate the healthy and leukemia free cells of white blood cells in bone marrow of patients and slowly-slowly cure the leukemia patients. Feline leukemia virus (FeLV) is retrovirus globally impact on the health and cause tumor and bone marrow disorder and immune suppression. The CAR-Natural Killer and CAR-macrophages were introduced as a complement or alternative to CAR-T cells therapy for solid tumor. The thiopurines interfere with the synthesis of nucleic acids in leukemia affected cells in the bone marrow and acting mainly in the S-phase of cell division process in cancerous cells and alloHSCT therapy use to combined targeted therapy and cure to certain types of acute myeloid leukemia which is create by TP53 mutations.The TPMT and NUDT15 genes evaluated their association with 6MP dose intensity and identified 5 and 6 coding variant in TPMT and NUDT15 respectively.
• Current advances in cancer treatment: A comprehensive review of therapeutic strategies and emerging innovations. Verma, Ankit; Rawat, Arvindra; Sahu, Vaishnavi; Chaurasia, Yogendra; Kumar, Amit; Rathore, Swati; Tripathi, Richa (2024). 18(1) 274–282.

  Cancer stands as a pressing global health crisis, claiming one in every six lives across the world. The treatment of cancer has evolved into a remarkably intricate endeavour. In recent years, there have been significant advancements in the field of cancer treatment, alongside the longstanding methods of surgery, chemotherapy, and radiotherapy. In the realm of oncology, there has been a surge of innovative treatments, encompassing stem cell therapy, targeted therapy, ablation therapy, nanoparticles, natural antioxidants, radionics, chemo dynamic therapy, sonodynamic therapy, and ferroptosis-based therapy. Contemporary oncology is predominantly dedicated to the progression of cancer nanomedicines, with notable promise found in stem cell therapy, offering the potential to rejuvenate and mend afflicted tissues at both primary and metastatic cancer sites. Nanoparticles have ushered in new avenues for both diagnosis and treatment. Targeted therapy presents a groundbreaking strategy that hinders the proliferation and dissemination of particular cancer cells, while minimizing harm to healthy ones. Ablation therapy, characterized by its minimally invasive nature, enables the elimination of cancer using methods like controlled burning or freezing, eliminating the necessity for open surgery. In the ongoing pursuit of improved cancer therapies, numerous innovative technologies are currently undergoing clinical trials, and some have already gained approval. This review provides a comprehensive update on the recent advancements and breakthroughs in the realm of cancer treatment.
• A case report on Sjogren syndrome with autoimmune liver disorder. R, Ranjana S; S, Sreelekshmy B; Dharan, Shaiju S; L, Drishya (2024). 18(1) 271–273.

  Background: Primary Sjogren’s syndrome (pSS) is a chronic systemic and autoimmune disorder characterized by inflammation and dysfunction of exocrine glands. Liver involvement was the first extraglandular manifestations to be reported in patients with pSS. Tubulointerstitial nephritis (TIN) is the main renal involvement associated with pSS and manifest as distal renal tubular acidosis (RTA), and others, of which RTA is the main clinical presentation. RTA has been reported in 4.3 to 9% of pSS patients. In this case, patient experiences RTA. Case Presentation: A 19 year old female patient was presented with complaints of abdominal pain, fatigue for 2 months and loose stools. She had history of autoimmune hepatitis and decompensated liver cirrhosis with portal hypertension (autoimmune), bilateral peroneal axonal neuropathy, grade II hepatic encephalopathy resolved and recurrent pustular lesion for past 2 years which rupture spontaneously and heals with scary. She also presented with recurrent hypokalemia which was corrected. No history of similar complaints among the family members. Conclusion: This case explains the autoimmune liver disorder with newly diagnosed primary sjogren’s syndrome associated with recurrent hypokalemia.
• COVID 19 Vaccination implementation among preparatory school students in Akaki Kality Sub city, Addis Ababa, Ethiopia. Assegu, Yirga Bieza; Bidu, Kassahun Tegegne; Mosa, Abdulaziz Abdulsemed; Bekele, Esulalem Abebe (2024). 18(1) 257–270.

  Coronavirus (COVID-19) is a global pandemic that has affected 229 countries and territories. Vaccines are one of the best ways to prevent and slow down transmission of COVID 19. Since students in school setting share teaching rooms, sport facilities, and other facilities like toilet and cafeteria, and have a higher number of social contacts, this study aimed to assess implementation of Vaccination against COVID 19 among preparatory school selected secondary preparatory schools in Akaki Kality Sub city, Addis Ababa, Ethiopia. Descriptive cross sectional study design using multistage random sampling technique was conducted among secondary school students in Akaki Kality sub city, Addis Ababa, Ethiopia from March 01 – 25, 2023. A total of 349 students proportionally allocated to five schools in Akaki Kality sub city were interviewed and focus group discussion were conducted with five catchment health center immunization focal persons. In this study, preparatory students had 44.6% knowledge and 17.5% practice regarding COVID 19 vaccination. Religion, residence, and the educational level of students’ parent were found associated with students’ knowledge on vaccination against COVID 19. Previous COVID 19 illness and knowledge of students were found to be associated with students’ vaccination practice against COVID 19. In comparison to other studies, relatively limited knowledge and poor practice were observed. Knowledge was found to be associated with students’ practices indicating the need for strengthening behavioral, risk communication and community engagement activities using religious leaders and different communication platforms. Additionally, to address vaccine related shortages, partnerships should be strengthened at different levels to enable direct purchases, utilization of group financing and donation options.
• Interaction between aqueous extract of Moringa oleifera leaves and rabeprazole in treatment of ethanol induced gastric ulcer in Wistar rats. Adugba, Augustine O.; Ogli, Sunday Adakole; Onahinon, Christian; Eru, Emmanuel O.; Akwaras, Nndunno (2024). 18(1) 250–256.

  Background: The effect of concomitant use of herbs and conventional drugs is not widely known because it hasn’t been a common practice especially among the elite and those resident at the urban centers but very common among the rural duelers for co-administered herbs/supplements and conventional drugs. This study was carried out to investigate the interaction between moringa oleifera and rabeprazole in gastric acid secretion. Methods: Twenty (20) adult Wistar albino rats of both sexes weighing 300-450 g were randomly allocated into four (4) groups of five (5) animals per group. Group 1 served as the control and was given normal saline without administration of acid alcohol. Animals in group 2 were given acid alcohol (0.25 ml 0f 36% HCl + 75% ethanol 0.25 ml/100 g body weight). Animals in group 3 were given 50 mg/100 g bw of Moringa oleifera 1 hour before acid alcohol was administered. Group 4 were given: Rabeprazole 20 mg /kg body weight + acid Alcohol (36% HCL 0.25 mls+ 75% Ethanol (0.25 mls). A 30% isoflorane (inhalational anesthesia) by API Manufacturer with FDA, UK, marketed by Macfes medical store, high level Markurdi, Benue State, Nigeria. And 3.5% isoflurane (of the mixture of isoflurane 30%) at 100% oxygen was soaked in a cotton wool and dropped in clean and covered plastic container, and was used to anesthetized the rats, for the purpose of the aqueous extracts administration through a gastric fistula created by a surgical procedure. 10 minutes after aqueous extracts administration, aliquot samples were collected over 4 hours. Gastric acid secretion was measured by titrating the aliquots to a phenolphthalein endpoint. Results: showed that Moringa Olefera significantly delayed the time of onset of action of rabeprazole when co-administered. Moringa alone was a better inhibitor of gastric acid secretion than moringa co-administered with rabeprazole. Conclusion: Moringa delays the time of onset of action of Rabeprazole when co-administered.
• To assess the impact of covid-19 on maintenance haemodialysis patients: A retrospective study in a tertiary care hospital in south Kerala. MUHAMMED, NIHAL; R, LEKSHMI; PRASAD, PRAVEENA R; CHANDRAN, CHINTHA; DHARAN, SHAIJU S (2024). 18(1) 293–304.

  COVID-19 was started as a global pandemic in March 2020. It is an infectious disease caused by the SARS COV-2 virus and it has affected the care and outcomes of patient treated with dialysis. Patients with CKD could be more vulnerable to a severe form of COVID-19. Higher risk of mortality caused by COVID-19 in haemodialysis patient is detected with older age, comorbidities and impaired immune response. Clinical presentation of COVID-19 on haemodialysis patient is fluctuating from asymptomatic or mild disease to severe life threatening illness. Initially, common symptoms were presented including fever, dry cough, fatigue, diarrhea and dyspnea. On computerized tomography scan patients had shown bilateral ground-glass opacities revealing that COVID-19 predominantly affected the respiratory system. Maintenance haemodialysis is the most widely used treatment for end stage CKD patients and it has the higher risk of initial mortality from coronavirus 2019. CKD is a severe medical entity with a higher prevalence of comorbid conditions, mostly including diabetes, hypertension, disproportionally affecting older adults. The aim of this study is to assess the impact of COVID-19 on maintenance haemodialysis patient and the objective of the study is to assess the mortality of COVID-19 on maintenance haemodialysis patient and risk factors associated with it and also the severity of COVID19 on maintenance haemodialysis patient. We performed a retrospective cross sectional study using 39 samples. The samples were collected from the case files of the patients who fulfill the inclusion criteria and then the collected data was statistically interpreted using SPSS software version 22.0 and then the severity and mortality of the COVID-19 on maintenance haemodialysis patient was analyzed. The final analysis included 39 patient who met the inclusion criteria .Here the incidence of COVID-19 on maintenance haemodialysis patient is more prone on 41-60 years of age.
• Exploring the potentialities of industrial hemp for sustainable rural development. de C Lambert, Caio Fernando; Filho, Evandro Alves Barbosa; Coronado, Karen Viviana Castaño; Malabadi, Ravindra B. (2024). 18(1) 305–320.

  This literature review paper explores the potential sustainable applications of industrial hemp, contextualizing it within the UN Agenda 2030 Sustainable Development Goals (SDGs). Hemp is a dioecious, herbaceous, anemophilous (wind-pollinated) annual crop that grows from one to five meters in height. However, monoecious varieties have been developed through breeding and selection. Historically versatile, Cannabis sativa L. has faced stigmatization and unfounded prohibitions, having played crucial roles in different civilizations, including during World War I. A member of the Cannabaceae family, it is a versatile non-psychoactive crop, with low concentrations of THC. Recently, the global market for hemp has grown. It is an eco-friendly option in the food, textile, pharmaceutical, and energy sectors. This study is based on bibliographic research covering primary and secondary sources, including technical reports, academic journals, and scientific repositories. The origin, characteristics and cultivation methods of industrial hemp are discussed, besides its practical applications, including the production of fibers, health food grains, medicinal phytocannabinoids, biofuels, sustainable biomass energy, and carbon offsetting. Its potential to contribute to sustainable agriculture and achieve SDG targets stands out, considering environmental benefits, product diversification, resistance, and integration into agroforestry systems. Regenerative agriculture is explored as a promising approach, aligned with the principles of sustainable agriculture and the SDGs, aiming to restore agricultural ecosystems, promote soil health, and improve climate resilience. The research highlights the importance of reforming cannabis-related policies to achieve goals relating to health, justice, and global partnerships, emphasizing the need for sustainable approaches to exploiting this natural resource.
• In-vitro anthelmintic activity of crude extracts of Zingiberaceae species commonly available in Mwanza, Tanzania. Marwa, Karol J; Mhalule, Magreth; Ruganuza, Deodatus (2024). 18(1) 321–327.

  Introduction: Resistance to commonly used anthelmintic drugs has been reported in many areas of the world. Natural products are good candidates for discovering more effective anthelmintic compounds. This study assessed the In-vitro activity of extracts from Curcuma longa, Zingiber officinale and Elettaria cardamomum. Methods: This study was an In-vitro experimental study involving Apporrectodea longa earthworms. The worms were treated with 20mls of both distilled water and ethanolic extracts of all plant species (at 20, 40 and 60mg/ml). Albendazole was used as a standard drug. Paralysis and death time were recorded. Results: The paralysis time for water extracts were 0.83 hrs, 1.22 hrs and 3.33 hrs at 20mg/ml for Elettaria cardamomum, Zingiber officinale and Curcuma longa respectively while death time was 2.00 hrs, 1.50 hrs and 7.61 hrs for Elettaria cardamomum, Zingiber officinale and Curcuma longa respectively. The paralysis time for ethanol extracts were 0.50 hrs, 0.58 hrs and 0.70 hrs at 20mg/ml for Elettaria cardamomum, Zingiber officinale and Curcuma longa respectively while death time was 1.00 hrs, 1.00 hrs and 1.64 hrs for Elettaria cardamomum, Zingiber officinale and Curcuma longa respectively. Elettaria cardamomum and Zingiber officinale recorded shorter paralysis time than albendazole at 20mg/ml. Conclusion: Zingiber officinale and Elettaria cardamomum have recorded promising In-vitro activity warranting for pharmacological and toxicological investigations.
• Case report on Pharmacogenetic guided warfarin dosing in a postoperative valve replacement patient. R, Subathra Devi; N, Gowtham; V, Arun (2024). 18(1) 247–249.

  Patient underwent mitral valve replacement with mechanical valve and was initiated on oral anticoagulation with standard dose of warfarin. She developed supra therapeutic INR levels. Genotyping of CYP2C9 and VKORC1 encoding genes revealed homozygous variation of CYP2C9*3*3 and heterozygous variation of VKORC1 G>A making her hypersensitive to warfarin. Based on this study result and Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline, a low dose of warfarin (0.5mg per day) was prescribed, to achieve a therapeutic INR of 2.5 to 3.5 and adverse drug effects were avoided.
• Prevalence and pattern of dyslipidemia among patients with ischemic stroke in a tertiary care center in south- south Nigeria. Nwafor, Chibuike Eze; Ogbak, Nicole Onep-Onne (2024). 18(1) 240–246.

  Background: Stroke is a major public health problem worldwide. Dyslipidemia is a significant risk factor for ischemic stroke, but its prevalence and characteristics in this population remain understudied. Therefore, this study aims to investigate the prevalence and patterns of dyslipidemia among individuals diagnosed with ischemic stroke in a tertiary care center in South-South Nigeria. Materials and Method: This is a retrospective hospital-based study on Ischaemic stroke patients admitted to GoodHeart Medical Consultant Hospital, Port- Harcourt, Rivers state, Nigeria, from July 2022 to June 2023. Results: The study comprised 33 subjects consisting of 18(54.5%) males and 15(45.5%) females. The mean age of the total population was 62.6 ± 12.49. The most prevalent age group was elderly (>61 years) 20 (60.6%). The females were older than the males with a mean age of 64.1 ± 2.50 and 61.3 ± 12.69 respectively. The overall prevalence of dyslipidaemia was 97%, whereas the most common form of dyslipidaemia was reduced HDL (57.6%). There was no significant difference in dyslipidaemia among male and female stroke patients, nevertheless 63.6% of the males had dyslipidaemia. Conclusion: Dyslipidaemia was common in the overall study population particularly reduced HDL and elevated LDL. The study revealed no statistically significant difference between gender and dyslipidaemia in stroke patients, nevertheless dyslipidaemia was more in the male stroke patients than females. Hence, prevention of dyslipidaemia as well as other risk factors is key to reducing the burden of stroke in our country.
• Teenagers’ future diabetes risk perception. Prabu, Shreeya; Zwick, Hana Catherine; Malkin, Robert Allen (2024). 18(1) 233–239.

  Asians are often thought to have a poor ability to predict their future risk of diabetes. We studied perceptions of Type 2 diabetes future risk in middle school and high school students. All students watched two short videos about Body Mass Index (BMI) and diabetes. Afterwards, 300 students, ranging from 7th to 10th graders, took a short survey in their physical education classes. The survey gauged basic knowledge about diabetes, BMI, their view on their future risk of diabetes and asked them about various risk factors. Contrary to common thought, Asian students understood that they might have a higher risk than their non-Asian counterparts, and many responses in the survey suggest that they knew about diet differences and other cultural factors that account for the difference in risk.
• Comparative effect of Callosobruchus maculatus (Pest) on different pulses. Shukla, Mansi; Paul, Newton (2024). 18(1) 328–331.

  Experiments were undertaken in room circumstances on variety of pulses to investigate the seed damage and weight loss caused by pulse beetle Callosobruchus maculatus. The pulses selected for the study of comparative effect of Callosobruchus maculatus were chick pea (desi chana) “Cicer arietinum”, golden gram (moong daal) “Vigna radiata”, field pea (matar) “Pisum sativum”, Lentil (Masur) “Lens culinaris” and Kabuli chana (Chola) “Cicer arietinum”. The selected five variety of pulses are infested with pulse beetles and kept the pulse boxes for forty-five days without disturbing the pulses.
• The Versatility of Himalayan Pink Salt Bricks: A Unique Blend of Aesthetic and Wellness. nazir, zunair (zunair nazir, ed.) (2024). 50(49) 54.

  This article explores the growing popularity of Himalayan pink salt bricks as both a decorative and wellness-enhancing feature in modern living spaces. Sourced from the ancient salt mines of the Himalayas, these natural salt bricks are rich in minerals and offer unique benefits, from air purification to the creation of serene environments. The article delves into their versatile applications, including salt walls, salt rooms, and kitchen décor, highlighting their aesthetic appeal and eco-friendliness. It also discusses their sustainability, low maintenance, and health benefits, particularly in wellness and relaxation spaces. Finally, the article touches on how PinkSaltWall.com provides custom solutions for integrating these bricks into homes and businesses.
• Single tendon transfer of the flexor carpi ulnaris for high radial nerve palsy. Zaizi, A; Maqrout, A El; Alami, R El; Kharmaz, M; Lamrani, MO; Berrada, MS (2024). 18(1) 332–335.

  Complete radial nerve palsy results in a lack of extrinsic extensors of the wrist, fingers and thumb. The optimal treatment of persistent hight radial nerve palsy is tendon transfer, which leads generally to acceptable results with better extension of the fingers and ability to grasp large objects. There are a multiple techniques of tendon transfers from a single to multiple one generally three tendons, however a single flexor carpi ulnaris tendon (FCU) transfer has some advantages, including simplicity, shorter operation time, less morbidity and less surgical scars, which can be important in some patients, particularly women. We present a case report of single tendon transfer of the FCU to the digital extensors for high radial nerve palsy secondary to closed diaphyseal humeral fracture.
• High-resolution digital surface models (DSMs) of the Urft River valley (Urft Reservoir) from 2020 and 2021, northern Eifel Mountains, western Germany. Stauch, Georg; Dörwald, Lukas; Esch, Alexander; Walk, Janek (2023).

  Affiliated publication: Stauch, G., Dörwald, L., Esch, A., Walk, J., 2023. 115 years of sediment deposition in a reservoir in central Europe: Topographic change detection. Earth Surface Processes and Landforms.
• Helmholtz resonator with two resonance frequencies by coupling with a mechanical resonator. Hoppen, H.; Langfeldt, F.; Gleine, W.; von Estorff, O. (2023). 559 117747.
• High-resolution digital elevation model (DEM) of the Urft River valley (Urft Reservoir) from 1897, northern Eifel Mountains, western Germany. Stauch, Georg; Dörwald, Lukas; Esch, Alexander; Walk, Janek (2023).

  Affiliated publication: Stauch, G., Dörwald, L., Esch, A., Walk, J., 2023. 115 years of sediment deposition in a reservoir in central Europe: Topographic change detection. Earth Surface Processes and Landforms.
• Only Time Will Tell: Modelling Information Diffusion in Code Review with Time-Varying Hypergraphs. Dorner, Michael; Smite, Darja; Mendez, Daniel; Wnuk, Krzysztof; Czerwonka, Jacek in ESEM ’22 (2022). 195–204.

  Background: Modern code review is expected to facilitate knowledge sharing: All relevant information, the collective expertise, and meta-information around the code change and its context become evident, transparent, and explicit in the corresponding code review discussion. The discussion participants can leverage this information in the following code reviews; the information diffuses through the communication network that emerges from code review. Traditional time-aggregated graphs fall short in rendering information diffusion as those models ignore the temporal order of the information exchange: Information can only be passed on if it is available in the first place. Aim: This manuscript presents a novel model based on time-varying hypergraphs for rendering information diffusion that overcomes the inherent limitations of traditional, time-aggregated graph-based models. Method: In an in-silico experiment, we simulate an information diffusion within the internal code review at Microsoft and show the empirical impact of time on a key characteristic of information diffusion: the number of reachable participants. Results: Time-aggregation significantly overestimates the paths of information diffusion available in communication networks and, thus, is neither precise nor accurate for modelling and measuring the spread of information within communication networks that emerge from code review. Conclusion: Our model overcomes the inherent limitations of traditional, static or time-aggregated, graph-based communication models and sheds the first light on information diffusion through code review. We believe that our model can serve as a foundation for understanding, measuring, managing, and improving knowledge sharing in code review in particular and information diffusion in software engineering in general.
• ASIAMPO AGEN SLOT 777 GAMPANG JACKPOT GAMPANG WEDE BERKALI-KALI. asiampo (asiampo, ed.) (2021). 21(4) 1278.

  ASIAMPO Merupakan Agen Slot 777 Gampang Menang Dengan Menyediakan Media Deposit Yang Aman Dan Terpercaya Online 24 Jam Nonstop Untuk Mempermudah Langkah Deposit Anda Ketika Ingin Bermain.
• A conceptual model for the interpretation of aeolian sediments from a semiarid high-mountain environment since the late glacial. Stauch, Georg (2019). 91(1) 24–34.

  Different interpretations of accumulation and preservation of aeolian sediments lead to divergent and sometimes contradictory palaeoclimate reconstructions. Although aeolian transport mainly occurs during dry climate, the preservation of the aeolian sediment is a critical factor in many environments in determining the nature of the aeolian sedimentary archive. Analysis of more than 200 optically stimulated luminescence ages for aeolian sands from Tibet shows four different aeolian phases of accumulation. Strong aeolian activity occurred during the last glacial maximum, but hardly any aeolian sediments are preserved. Consequently, the period with the highest aeolian activity is not recorded in the sedimentary record. A phase of aeolian accumulation occurred in the late glacial and the early Holocene. The duration of deposition for this phase is a consequence of the complex topography and an increase in moisture. This phase was punctuated by exceptionally strong accumulation during the Younger Dryas stade. The mid-Holocene is characterised by weak aeolian accumulation and fluvial erosion caused by greater precipitation during the maximum height of the Asian summer monsoon. Aeolian activity resumed in the late Holocene because of drier conditions. The conceptual model provides an approach that can be applied to other mountain and desert margin regions that have limited sediment availability.
• Late Quaternary environments in the Gobi Desert of Mongolia: Vegetation, hydrological, and palaeoclimate evolution. Yu, Kaifeng; Lehmkuhl, Frank; Schlütz, Frank; Diekmann, Bernhard; Mischke, Steffen; Grunert, Jörg; Murad, Waheed; Nottebaum, Veit; Stauch, Georg; Zeeden, Christian (2019). 514 77–91.
• Paleolakes in the Gobi region of southern Mongolia. Lehmkuhl, Frank; Grunert, Jörg; Hülle, Daniela; Batkhishig, Ochirbat; Stauch, Georg (2018). 179 1–23.
• Environmental changes during the late Pleistocene and the Holocene in the Gonghe Basin, north-eastern Tibetan Plateau. Stauch, Georg; Lai, Zhongping; Lehmkuhl, Frank; Schulte, Philipp (2018). 509 144–155.
• Response of lake-catchment processes to Holocene climate variability: Evidences from the NE Tibetan Plateau. Yan, Dada; Wünnemann, Bernd; Zhang, Yongzhan; Long, Hao; Stauch, Georg; Sun, Qianli; Cao, Guangchao (2018). 201 261–279.
• Geochemical imprints of coupled paleoenvironmental and provenance change in the lacustrine sequence of Orog Nuur, Gobi Desert of Mongolia. Yu, Kaifeng; Lehmkuhl, Frank; Diekmann, Bernhard; Zeeden, Christian; Nottebaum, Veit; Stauch, Georg (2017). 58(4) 511–532.

  In the arid environment, due to the scarcity of a continuous terrestrial archive, lacustrine sequences are often employed as a paleoenvironmental repository. However, numerous spatial and temporal heterogeneities exist concerning previously studied sites in arid central Asia. Furthermore, surveys using a XRF core scanning technique on lacustrine sequences retrieved in hyperarid desert settings are largely rare. Hence, two parallel sediment cores (ONW I; ONW II) were retrieved from Orog Nuur, in the Gobi Desert of Mongolia. Continuous, high-resolution elemental abundances at a 1-cm scanning step size were examined in core ONW II using XRF core scanning. To constrain the data quality, elements with high error margins relative to measured peak areas and those elements/proxies below the significance level during the multivariate statistics are excluded for environmental/provenance implications. Based on multivariate statistical evaluation, the bulk-geochemistry of the core sediments are governed by (1) grain-size composition, (2) authigenic productivity (Ca, Cl, CaCO3) in an alkaline environment, (3) allochthonous organic material (TOC and C/Natomic), and (4) terrigenous input via fluvial inflows, as well as quasi-constant aeolian input through the late Quaternary (Al, Si, K, Ti, and Fe). Disparate source lithotypes, as well as authigenic productivity of the lake system existed before and after Termination I. The Holocene was dominated by a distinct high productivity alkaline environment with more felsic and alkaline input relative to the late Pleistocene. This might be attributed to an increased hydrodynamic strength of riverine inflow and/or intensified erosion and weathering of felsic source rocks in the upper catchment of the Orog Nuur. Therefore, in order to gain a better understanding of the bulk-geochemistry of lake sediments, the coupled provenance and environmental signatures, as well as land surface processes in the catchment need to be systematically discerned. Thus, the XRF core scanning data obtained in this study would have practical and complimentary merit for other lacustrine studies focused on the desert realm across the globe.
• Late Pleistocene glaciations at Lake Donggi Cona, eastern Kunlun Shan (<scp>NE</scp> Tibet): early maxima and a diminishing trend of glaciation during the last glacial cycle. Rother, Henrik; Stauch, Georg; Loibl, David; Lehmkuhl, Frank; Freeman, Stewart P. H. T. (2017). 46(3) 503–524.
• Landscape and climate on the northern Tibetan Plateau during the late Quaternary. Stauch, G.; Schulte, P.; Ramisch, A.; Hartmann, K.; Hülle, D.; Lockot, G.; Diekmann, B.; Nottebaum, V.; Müller, C.; Wünnemann, B.; Yan, D.; Lehmkuhl, F. (2017). 286 78–92.
• Aeolian sediments on the northern Tibetan Plateau Stauch, Georg (G. Stauch, ed.) (2017).
• Project house water: a novel interdisciplinary framework to assess the environmental and socioeconomic consequences of flood-related impacts. Crawford, Sarah E.; Cofalla, Catrina Brüll nee; Aumeier, Benedikt; Brinkmann, Markus; Classen, Elisa; Esser, Verena; Ganal, Caroline; Kaip, Elena; Häussling, Roger; Lehmkuhl, Frank; Letmathe, Peter; Müller, Anne-Katrin; Rabinovitch, Ilja; Reicherter, Klaus; Schwarzbauer, Jan; Schmitt, Marco; Stauch, Georg; Wessling, Matthias; Yüce, Süleyman; Hecker, Markus; Kidd, Karen A.; Altenburger, Rolf; Brack, Werner; Schüttrumpf, Holger; Hollert, Henner (2017). 29(1)
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